1. Searches may be conducted using any of the terms below (comma or line-separated for multiple terms). Which terms are searched for can be toggled in the "Fields Searched" section. By default, the tool is set to search by:
    • WormBaseID (e.g., WBGene00003001)
    • Common Worm Gene Name (e.g., lin-12)
    • Worm Locus ID (e.g., R107.8)
    • Human Ensembl ID (e.g., ENSG00000148400)
    • Human HGNC-approved symbol (e.g., NOTCH1)

    If desired, a user can also, or instead, search by:
    • SMART IDs (e.g., SM0004)
    • InterPro ID or description (e.g. IPR000800 or “Notch domain”)
    • OMIM ID or description (e.g. 616028 or “Adams-Oliver syndrome 5”)

  2. C. elegans gene identifiers are from WormBase release WS257 (2017-02) and human gene identifiers are from Ensembl v89 (2017-05). Common worm gene names and HGNC IDs assigned after these releases are not reflected in our database and searching with these newer identifiers will not work.

  3. For gene-based searches we recommend using WormBaseID's for C. elegans genes, as this is likely the most stable identifier. For human genes, the HGNC-approved symbol appears to be the most stable, but not all human genes have an HGNC ID.

  4. We recommend using IDs/Accessions, instead of descriptions, when possible for domain or phenotype-based searches. Descriptions may not work if the input is not identical to the description stored in the database. Therefore, IDs/accession will return the most precise results. IDs can be found at:
    • SMART: This page provides a table of the protein domains identified by SMART. Clicking on a domain name will bring up a page with the associated SMART ID (SMXXXX).
    • InterPro: This page provides an input box where a domain of interest can be introduced and the corresponding InterPro ID (IPRXXXXXX) will be retrieved.
    • OMIM: This page provides search capability to find human disease-gene association and their corresponding Phenotype MIM numbers (6 digit). Please be sure to use the "Phenotype MIM number" and not the "Gene/Locus MIM number".

  5. We recommend only using the "Partial match allowed" option for HGNC name-based searches when all members of a gene family (e.g., so that a search for “Notch” will return human NOTCH1, NOTCH2, NOTCH3 and NOTCH4). Allowing partial matches for entries in other fields (particularly InterPro descriptions) will return undesired results.

    We are always looking for ways to improve this online tool. If you have any feedback or questions please email Dan Shaye.