Searches may be conducted using any of the terms below (comma or line-separated for multiple terms). Which terms are searched for can be toggled in the "Fields Searched" section. By default, the tool is set to search by:
- WormBaseID (e.g., WBGene00003001)
- Common Worm Gene Name (e.g., lin-12)
- Worm Locus ID (e.g., R107.8)
- Human Ensembl ID (e.g., ENSG00000148400)
- Human HGNC-approved symbol (e.g., NOTCH1)
If desired, a user can also, or instead, search by:
- SMART IDs (e.g., SM0004)
- InterPro ID or description (e.g. IPR000800 or “Notch domain”)
- OMIM ID or description (e.g. 616028 or “Adams-Oliver syndrome 5”)
- C. elegans gene identifiers are from WormBase release WS257 (2017-02) and human gene identifiers are from Ensembl v89 (2017-05). Common worm gene names and HGNC IDs assigned after these releases are not reflected in our database and searching with these newer identifiers will not work.
- For gene-based searches we recommend using WormBaseID's for C. elegans genes, as this is likely the most stable identifier. For human genes, the HGNC-approved symbol appears to be the most stable, but not all human genes have an HGNC ID.
- We recommend using IDs/Accessions, instead of descriptions, when possible for domain or phenotype-based searches. Descriptions may not work if the input is not identical to the description stored in the database. Therefore, IDs/accession will return the most precise results. IDs can be found at:
- SMART: This page provides a table of the protein domains identified by SMART. Clicking on a domain name will bring up a page with the associated SMART ID (SMXXXX).
- InterPro: This page provides an input box where a domain of interest can be introduced and the corresponding InterPro ID (IPRXXXXXX) will be retrieved.
- OMIM: This page provides search capability to find human disease-gene association and their corresponding Phenotype MIM numbers (6 digit). Please be sure to use the "Phenotype MIM number" and not the "Gene/Locus MIM number".
We are always looking for ways to improve this online tool. If you have any feedback or questions please email Dan Shaye.